Endocrine Abstracts

Introduction: Premature ovarian failure (POF) is defined as amenorrhea lasting more than four months before the age of 40 with a high level of gonadotropins in at least two separate samples. The aim of this work was to describe the etiological profile of a series of Tunisian women followed for POF.Patients and methods: It is a descriptive study of 42 cases of POF collected in the endocrinology department of Sousse between 2000 and 2017.<p class="abst...

Introduction: Central diabetes insipidus (CDI) is a heterogeneous condition characterized by the presence of polyuria and polydipsia due to a deficiency of arginine vasopressin. Frequently, CDI is wrongly considered idiopathic if not associated with other signs and symptoms.Case report: We report the case of a 50-year-old woman diagnosed with idiopathic central diabetes insipidus at the age of 34. The MRI scan of the hypothalamus and pituitary gland was ...

Introduction: Leydig cell tumors (LCTs) are uncommon neoplasms arising from gonadal stroma, accounting for 1–3% of all testicular tumors in adults. The etiology of LCT remains unclear. About 25% of LCTs secrete predominantly estrogens, which produce gynecomastia.Observation: We report a case of a 53-year-old male patient who sought evaluation for bilateral gynecomastia. He had a long-term use of amitriptyline and benzodiazepine. The physical examin...

Introduction: Medullary thyroid carcinoma (MTC) represents 3–10% of all thyroid cancer. The presence of papillary thyroid microcarcinoma (mPTC) in patients undergoing thyroidectomy for multinodular goiter has been reported as 3–7%.The occurrence of multiple thyroid cancers of different origin in one individual patient is a rare event. We report the case of synchronous papillary and medullary thyroid cancer developed in heterogynous recurrent ...

BackgroundThe thyroid nodule is a common presentation. Its prevalence is estimated to be 5%. Surgical treatment could not be systematic. It requires structured diagnostic approach to ascertain the risk of malignancy and determine appropriate management.AimTo evaluate potential role of epidemiological, clinical and para clinical criteria as preoperative indcators of malignancy in thyroid nodules.<p class="...

Introduction: Disorders of sex development represent a rare group of congenital disorders causing discord between the phenotypical and genotypical sex. We present the case of two female patients in whom we discovered a sex development disorder when they consulted for amenorrhea.Case report: Two sisters of 21 and 25 years old had an endocrinological consult for primary amenorrhea. They were conceived from a consanguineous marriage and had no particular me...

Introduction: Congenital adrenal hyperplasia (CAH) due to an enzymatic defect in 11-beta-hydroxylase (11β-OHD) is the second most common cause of CAH representing 5-8% of cases. It is characterized by androgen excess, hypertension and hypokalemia. Here we describe the case of a patient having a CYP11B1 mutation and being followed-up during 33 years.Observation: A 36-year-old Tunisian male was diagnosed with 11β-OHD at the age of three years rev...